"VSports在线直播" lncRNA-dependent mechanisms of androgen-receptor-regulated gene activation programs

V体育平台登录 - Epigenetic silencing of miRNA-338-5p and miRNA-421 drives SPINK1-positive prostate cancer

Bhatia1, Yadav2, Tiwari3 et al. 2018Preprint262190Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task VSports app下载. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Numerous lncRNAs have been reported to be dysregulated in prostate cancer (51,52), for instance, PCGEM1 and PRNCR1 are highly expressed in aggressive PCa and enhance the AR-mediated gene activation program (53). Furthermore, MALAT1 renders cell cycle arrest in G1/S transition and mitotic phase by modulating the expression of E2F1 and B-MYB (25). …”Section: Discussionmentioningconfidence: 99%

Epigenetic silencing of miRNA-338-5p and miRNA-421 drives SPINK1-positive prostate cancer

Bhatia1, Yadav2, Tiwari3 et al. 2018Preprint262190Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…In another study, PRNCR1 and PCGEM1 were perturbed and indicated to be involved in inhibiting PYGO2 function in AR‐dependent promoter/enhancers in castration‐resistant prostate cancer 73. However, PRNCR1 and PCGEM1 were then shown not to be involved in castration‐resistant prostate cancer 74. …”Section: Methods Utilized For Determination Of Lncrna Functionmentioningconfidence: 99%

"V体育2025版" State of the art technologies to explore long non‐coding RNAs in cancer

Salehi1, Taheri2, Azarpira3 et al. 2017J Cellular Molecular Medi750670Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Another study shows that two lncRNAs, PRNCR1 and PCGEM1, bind to androgen receptor and are required for ligand-dependent activation of androgen receptor pathway. Moreover, their pathological up-regulation can trigger ligand-independent activation of androgen receptor pathway and may facilitate castration resistance in prostatic tumors [49]. These examples have raised the possibility that lncRNAs may play significant roles in tumor cell plasticity by being involved in regulation of critical signal pathways. …”Section: Lncrnas In Cancermentioningconfidence: 99%“…While genetic knock-outs of certain protein-coding genes are often achieved by introducing a stop Activate androgen-receptor pathway and facilitate castration-resistance in prostate cancer [49] codon in the translated sequences, this strategy is not applicable for long non-coding RNA transcripts as the transcripts themselves are the functional units. Other knock-out strategies such as disruption of core promoters of ncRNA genes are complicated by the nature that ncRNAs genes are often associated with protein-coding genes. …”Section: Concluding Remarks and Future Perspectivesmentioningconfidence: 99%

Non-coding RNAs regulate tumor cell plasticity

Liu1, Sun2, Song3 2013Sci. China Life Sci. 140110Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.