Thymic Damage, Impaired Negative Selection, and Development of Chronic Graft-versus-Host Disease Caused by Donor CD4+ and CD8+ T Cells

MHC-Mismatched Chimerism Is Required for Induction of Transplantation Tolerance in Autoimmune Nonobese Diabetic Recipients

Wang1, Racine2, Zhang3 et al. 2014The Journal of ImmunologySelf Cite172180Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…We found that MHC-matched chimerism cannot tolerize the residual radiation-resistant autoreactive T memory cells with alloreactivity in the periphery, but infusion of donor CD8 + T cells could eliminate those T memory cells via GVA effect. Unfortunately, consistent with our recent report (50,51), the alloreactive donor CD8 + T cells also caused chronic GVHD in TBI-conditioned recipients VSports. In contrast, MHCmismatched chimerism induced with donor TCD-BM can tolerize the radiation-resistant autoreactive T memory cells in the periphery in a mismatched MHC II-dependent manner. …”Section: Discussionsupportingconfidence: 90%

MHC-Mismatched Chimerism Is Required for Induction of Transplantation Tolerance in Autoimmune Nonobese Diabetic Recipients (VSports app下载)

Wang1, Racine2, Zhang3 et al. 2014The Journal of ImmunologySelf Cite172180Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…We would emphasize again that conditioning with lowdose CY, PT, and ATG as well as transplanting BM and lowdose CD4 + T-depleting spleen cells, that is, low numbers of donor CD8 + T cells, induced mixed chimerism in most of the recipients. Mixed chimerism does not cause GVHD, and the key for MHC-mismatched mixed chimerism to restore central tolerance is the lack of GVHD; otherwise, GVHD itself damages thymic mTEC and worsens autoimmunity, as we have reported (35). We should point out that this conditioning regimen can result in complete chimerism that has the potential to develop chronic GVHD when high numbers of donor CD8 + T cells are infused. …”Section: Discussionmentioningconfidence: 67%

V体育官网入口 - MHC-mismatched mixed chimerism augments thymic regulatory T-cell production and prevents relapse of EAE in mice

Wu1, Li2, Zhang3 et al. 2015Proc. Natl. Acad. Sci. U. S. A. Self Cite150150Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…The infused alloreactive CD8 + T cells in the anti-CD3/CD8-conditioned recipients gradually became tolerized or regulatory (19,24). This can explain our observation that although [30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45] can take away survival factors and result in apoptosis of autoreactive T1 B cells. We should point out that MeyerBahlburg et al (39), however, did further separate the T1 subset into CD21…”Section: Discussionmentioningconfidence: 93%“…The recipients were injected with CD4 + T-depleted spleen cells that contained ;10% CD8 + T cells. Alloreactive CD8 + T cells were able to effectively kill host-type T and B cells (20,25), but they also caused graft versus host disease (GVHD) in TBI-conditioned recipients (42). However, in the anti-CD3/CD8-conditioned recipients, the alloreactive donor T cells are confined to lympho-hematopoietic tissues and are prevented from migration into GVHD target tissues to cause GVHD. …”Section: Discussionmentioningconfidence: 99%

Induction of Mixed Chimerism Depletes Pre-existing and De Novo–Developed Autoreactive B Cells in Autoimmune NOD Mice

Racine1, Wang2, Zhang3 et al. 2014DiabetesSelf Cite110130Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 3 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.