Normalizing Tumor Microenvironment to Treat Cancer: Bench to Bedside to Biomarkers

Physical exercise as chemosensitizer

Vaccarezza1 2014Clin Exp Med2010Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC) VSports app下载. Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…It would be interesting to assess the relative contribution of several types of exercise to these changes in endothelial permeability as well potential molecular mechanisms, keeping in mind a potential translation to these findings to clinical oncology. Of note, this provocative data are of interest even for blood cancers, considering the established role of bone marrow angiogenesis in the outcome of solid cancers and haematologic malignancies [3][4][5]. More experimental proof is definitely needed in animal models and in humans to support these results. …”mentioningconfidence: 86%“…Intriguingly, a proposed mechanism is the ''normalization'' of the endothelial layer that is defective in tumours, and it represents a formidable barrier to efficient drug delivery [3,4]. It would be interesting to assess the relative contribution of several types of exercise to these changes in endothelial permeability as well potential molecular mechanisms, keeping in mind a potential translation to these findings to clinical oncology. …”mentioningconfidence: 99%“…More experimental proof is definitely needed in animal models and in humans to support these results. Nevertheless, this is a possible inexpensive and valuable way to enhance drug potency [3,4], with obvious translational effects in a clinical setting and possibly in cancer survival. Physical exercise science is coming of age not only in rehabilitation clinical haematology/oncology, but also as a potential therapeutic tool. …”mentioningconfidence: 99%See 1 more Smart Citation

Physical exercise as chemosensitizer

Vaccarezza1 2014Clin Exp Med2010Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…The vascular normalization strategy on the other hand, which has been used in the clinic during the last 10 years [9,23], is based on the notion that the tumor vasculature needs to be brought closer to a more "normal" state to be functional. Vascular normalization is achieved with judicious doses of anti-angiogenic drugs, targeting mainly Vascular Endothelial Growth Factor (VEGF) or its receptors. …”Section: Strategies To Improve Drug Deliverymentioningconfidence: 99%“…Similarly, pharmacologic depletion of CAFs has shown to reduce intratumoral stresses, improving perfusion, drug delivery and overall survival in pancreatic and breast tumor models [19,20]. However, genetic deletion of CAFs might enhance tumor progression [21,22]. The vascular normalization strategy on the other hand, which has been used in the clinic during the last 10 years [9,23], is based on the notion that the tumor vasculature needs to be brought closer to a more "normal" state to be functional. Vascular normalization is achieved with judicious doses of anti-angiogenic drugs, targeting mainly Vascular Endothelial Growth Factor (VEGF) or its receptors. …”mentioningconfidence: 99%

Targeting Inflammation to Improve Tumor Drug Delivery (VSports app下载)

Gkretsi1, Zacharia2, Stylianopoulos3 2017Trends in Cancer290300Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract

Effect of Bevacizumab in Combination With Standard Oxaliplatin-Based Regimens in Patients With Metastatic Colorectal Cancer

Avallone1, Piccirillo2, Nasti3 et al. 2021JAMA Netw Open270170Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.