VSports注册入口 - Requirement of phosphorylatable endothelial nitric oxide synthase at Ser-1177 for vasoinhibin-mediated inhibition of endothelial cell migration and proliferation in vitro

Dual contribution of TRPV4 antagonism in the regulatory effect of vasoinhibins on blood-retinal barrier permeability: diabetic milieu makes a difference

Zamarripa1, Imm2, Cortés3 et al. 2017Sci RepSelf Cite3334442Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…So far, vasoinhibins have not been related to any stimuli known to activate TRPV4 (i. e. , cell swelling, low pH, mechanical stress, and temperature 115–119 ), and TRPV4 has not been related to the few described binding sites for vasoinhibins 120,121 , but vasoinhibins may indirectly regulate TRPV4 by interfering with both receptor-operated Ca 2+ entry 14,16,17 and NO production 10,13,14,122 . …”Section: Discussionmentioningconfidence: 99%“…Vasoinhibins reduce NO production by limiting eNOS activation through Ca 2+ /calmodulin, and also by causing its dephosphorylation by protein phosphatase 2A 10,13,14,122 . NO has been shown to inactivate TRPV4 by two mechanisms: (i) inducing TRPV4 S-nitrosylation on the Cys 8,53 residue, which reduces the channel sensitivity to 4-αPDD and its interaction with calmodulin 123 , and (ii) increasing cGMP that inhibits TRPV4 by PKG-mediated phosphorylation 124 . …”Section: Discussionmentioningconfidence: 99%

Dual contribution of TRPV4 antagonism in the regulatory effect of vasoinhibins on blood-retinal barrier permeability: diabetic milieu makes a difference

Zamarripa1, Imm2, Cortés3 et al. 2017Sci RepSelf Cite3334442Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD) VSports app下载. Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Also, dephosphorylation-mediated inactivation of eNOS can contribute to vasoinhibin inhibition of endothelial cell proliferation and migration. Vasoinhibins block the increase in eNOS activity, migration, and proliferation of endothelial cells overexpressing wild type eNOS but did not affect these responses in cells overexpressing phosphomimetic or nonphosphorylatable eNOS mutants [48]. …”Section: Vascular Effects Of Prl and Vasoinhibinsmentioningconfidence: 87%

Regulation of Blood Vessels by Prolactin and Vasoinhibins

Clapp1, Thébault2, Macotela3 et al. 2014Advances in Experimental Medicine and BiologySelf Cite74411401Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…eNOS is one of the NOS isoforms that are constitutively expressed in endothelial cells. Nitric oxide, which is produced by eNOS, protects endothelial cells against apoptosis and promotes angiogenesis (16), and Vi inhibits eNOS activity through dephosphorylation (17). Moreover, Vi downregulates expression of inducible NOS, which is another NOS isoform (18). …”Section: Discussionmentioningconfidence: 99%“…The activation of eNOS was induced by increase of intracellular Ca 2+ mobilization (22) and phosphorylation (23) through VEGF and VEGF-R2. In contrast, Vi inhibits both intracellular Ca 2+ mobilization (7) and phosphorylation of eNOS (17). Moreover, Vi inhibits angiogenesis signaling through inhibiting Ras, which is one of the starting point of VEGF signaling (14). …”Section: Discussionmentioningconfidence: 99%

Vasoinhibin, an N-terminal Prolactin Fragment, Directly Inhibits Cardiac Angiogenesis in Three-dimensional Heart Culture

Nakajima1, Nakamura2, Harigaya3 2017Front. Endocrinol. 14090Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.