VSports最新版本 - Structures of the human and Drosophila 80S ribosome

Specific RNP capture with antisense LNA/DNA mixmers

Rogell1, Fischer2, Rettel3 et al. 2017RNA511820Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…eiF3J, SERBP1, and LRPPRC were specifically enriched in the 18S rRNA interactome data sets, whereas PA2G4, HNRNPC, HNRNPD, BTF3, HNRNPA2B1, HNRNPM, PLIN4, and DSG1 were identified as specific components of the 28S rRNA interactome. SERBP1 (also known as plasminogen activator inhibitor 1 RNA-binding protein) was previously identified within the structure of the 80S ribosome, mostly in association with the 40S subunit (Anger et al 2013). This is consistent with the observed interaction of SERBP1 with the 18S rRNA. …”Section: Determination Of the Rrna Interactomes Of Hela Cells By Specsupportingconfidence: 73%“…Rpl8 was identified in previous screens as a potential ribosome biogenesis factor (Wild et al 2010;Badertscher et al 2015) and could potentially interact with both the 18S and the 28S rRNA by residing close to the intersubunit space (Anger et al 2013). However, the signal intensity for Rpl8 in the 18S rRNA interactome is similar to that in the 28S scrambled control data set (Fig. …”Section: Determination Of the Rrna Interactomes Of Hela Cells By Specmentioningconfidence: 62%“…When a limited number of nucleotides exhibited complementarity with a nontarget RNA, we avoided insertion of LNA at these positions. In addition, probes were designed to hybridize to regions lacking detectable stable secondary structures, as determined with mfold (Zuker 2003) or from published structural information for the rRNAs (Anger et al 2013). FIGURE 1. …”Section: Resultsmentioningconfidence: 99%“…Little is known about nonribosomal proteins binding to the ribosome, especially those that interact with the so-called expansion segments that distinguish mammalian rRNAs from those of lower eukaryotes and bacteria (Gerbi 1996;Melnikov et al 2012;Anger et al 2013). We designed specific LNA/DNA probes targeting regions of the 18S and 28S rRNAs that are predicted to be mostly single-stranded. …”Section: Determination Of the Rrna Interactomes Of Hela Cells By Specmentioningconfidence: 99%See 2 more Smart Citations

Specific RNP capture with antisense LNA/DNA mixmers

Rogell1, Fischer2, Rettel3 et al. 2017RNA511820Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…The ''gold standard'' for characterizing molecular interactions of RBDs with their cognate RNA molecules by structure determination is co-crystallization [4,5]; others include NMR of the complex [6], or high-resolution EM of entire RNPs, as performed for the ribosome [7]. Although the number of co-structures of RBPs has been steadily increasing with more than 200 co-structures of protein-RNA complexes available in the PDB, most RBPs are still crystallized without RNA. …”Section: Introductionmentioningconfidence: 99%

Analysis of protein–RNA interactions in CRISPR proteins and effector complexes by UV-induced cross-linking and mass spectrometry (VSports手机版)

Sharma1, Hrle2, Kramer3 et al VSports app下载. 2015Methods300390Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract

VSports手机版 - Comparison of preribosomal RNA processing pathways in yeast, plant and human cells – focus on coordinated action of endo‐ and exoribonucleases

Tomecki1, Sikorski2, Zakrzewska‐Placzek3 2017FEBS Letters12221670Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.