"VSports在线直播" TMEM16F (Anoctamin 6), an anion channel of delayed Ca2+ activation

VSports在线直播 - Cl− channels in apoptosis

Wanitchakool1, Ousingsawat2, Sirianant3 et al. 2016Eur Biophys J421330Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…For ANO6/ TMEM16F, a similar role has been described recently (Juul et al 2014;Ousingsawat et al 2015;Sirianant et al 2015). ANO6 is a Ca 2+ -activated phospholipid scramblase that may also operate as a Ca 2+ -activated Cl − or nonselective ion channel (Grubb et al 2013;Kunzelmann et al 2014;Shimizu et al 2013;Suzuki et al 2010;Tian et al 2012;Yang et al 2012). We found that ANO6 is activated by hypotonic cell swelling, or, alternatively, controls the activity of VRAC . …”Section: Role Of Tmem16f/ano6 In Volume Regulation and Regulated Cellsupportingconfidence: 77%

Cl− channels in apoptosis

Wanitchakool1, Ousingsawat2, Sirianant3 et al. 2016Eur Biophys J421330Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Ano6 has attracted large attention due to its properties as a Ca 2+ -activated phospholipid scramblase and Ca 2+ -activated Cl − channel (for review see Kunzelmann et al [26]). Despite earlier controversies arguing against the role of Ano6 as a Cl − permeable ion channel [54], it has now been clearly shown by several independent groups, to produce a large conductance Cl − permeable channel activated by strong (≥10 μM) increase in intracellular Ca 2+ [15,21,30,31,46,49]. Moreover, Ano6 has been shown to be activated during cellular volume regulation and apoptotic cell death [1,20,21,31]. …”Section: Discussionmentioningconfidence: 99%

Anoctamins support calcium-dependent chloride secretion by facilitating calcium signaling in adult mouse intestine

Schreiber1, Faria2, Skryabin3 et al. 2014Pflugers Arch - Eur J Physiol8011700Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Although TMEM16A and TMEM16B are clearly Ca 2+ -activated Cl -channels (Caputo et al, 2008;Schroeder et al, 2008;Yang et al, 2008), the physiological functions of other members of the TMEM16 family have been dubious (Duran and Hartzell, 2011). For example, although TMEM16F certainly is a phospholipid scramblase (Suzuki et al, 2010), it has also been reported to be a nonselective cation channel Adomaviciene et al, 2013) and various types of Cl -channel (Almaç a et al, 2009;Martins et al, 2011;Szteyn et al, 2012;Grubb et al, 2013;Shimizu et al, 2013;Juul et al, 2014). The crystal structure of nhTMEM16 does not reveal an obvious alternative pathway for ion permeation through the bilayer other than the path taken by phospholipids and we have proposed that the ion conductance of TMEM16F represents a leak of ions through the aqueduct that occurs during lipid scrambling (Yu et al, 2015). …”Section: Mechanisms Of Ion Transportmentioningconfidence: 99%

VSports - Lipids and Ions Traverse the Membrane by the Same Physical Pathway in the nhTMEM16 Scramblase

Jiang1, Yu2, Hartzell3 et al. 2018Biophysical Journal179290Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD) VSports app下载. Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 3 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.