Val-BoroPro Accelerates T Cell Priming via Modulation of Dendritic Cell Trafficking Resulting in Complete Regression of Established Murine Tumors

A pan inhibitor of DASH family enzymes induces immunogenic modulation and sensitizes murine and human carcinoma cells to antigen-specific cytotoxic T lymphocyte killing: implications for combination therapy with cancer vaccines

Donahue1, Duncan2, Fry3 et al. 2014VaccineSelf Cite130110Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…In previous studies, DASH inhibitors PT-100 and ARI-4175 were shown to upregulate cytokine and/or chemokine expression, modulate the trafficking of DCs and immunoregulatory cells, and activate or accelerate T-cell dependent immune responses against solid tumors [9, 10]. Our present studies revealed a new aspect of the antitumor activity of ARI-4175: the direct sensitization of tumor cells to T-cell mediated killing. …”Section: Discussionsupportingconfidence: 51%

A pan inhibitor of DASH family enzymes induces immunogenic modulation and sensitizes murine and human carcinoma cells to antigen-specific cytotoxic T lymphocyte killing: implications for combination therapy with cancer vaccines

Donahue1, Duncan2, Fry3 et al. 2014VaccineSelf Cite130110Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Inhibition of DPP8 and DPP9, but not DPPIV, is responsible for vildagliptin's enhancement of parthenolide's cytotoxicity (73). In addition, inhibition of DPP8 and DPP9 probably contributes to the tumor regression induced by the compound Val-boroPro (74). Moreover, a separate study suggests that the DPPs act as survival factors in the Ewing Sarcoma Family of Tumors (51). …”Section: Dpp8 and Dpp9 In Cell Behavior And Tumor Biologymentioningconfidence: 99%

Advances in Understanding the Expression and Function of Dipeptidyl Peptidase 8 and 9

Zhang1, Chen2, Keane3 et al. 2013Molecular Cancer Research871620Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC) VSports app下载. Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…1a) is a nonselective inhibitor of the S9 family of post-proline cleaving serine proteases, including DPP4, DPP7, DPP8, DPP9, and FAP, and has been demonstrated to induce dramatic tumor regressions in multiple mouse models of cancer 7,8 . The responses are immune-mediated, as the efficacy of Val-boroPro is dramatically attenuated in lymphocyte-deficient mice and Val-boroPro-treated mice that have rejected their tumors become immune to rechallenge 7 . …”Section: Introductionmentioningconfidence: 99%“…The responses are immune-mediated, as the efficacy of Val-boroPro is dramatically attenuated in lymphocyte-deficient mice and Val-boroPro-treated mice that have rejected their tumors become immune to rechallenge 7 . Val-boroPro is known to stimulate the transcriptional upregulation several cytokines, including IL-1β, IL-6, G-CSF, and CXCL1/KC, in both tumors and tumor-draining lymph nodes 7 , and to increase the mouse serum protein levels of several of these cytokines, including G-CSF and CXCL1/KC 7,8 . Bone marrow-derived cells appear to be key mediators of the antitumor immune response, as Val-boroPro has been reported to induce cytokines from bone marrow stromal cells 9 and from co-cultures of THP-1 macrophages and fibroblasts in vitro 9,10 , and clodronate depletion of phagocytic cells significantly reduces Val-boroPro’s antitumor activity in vivo 8 . …”Section: Introductionmentioningconfidence: 99%“…Val-boroPro is known to stimulate the transcriptional upregulation several cytokines, including IL-1β, IL-6, G-CSF, and CXCL1/KC, in both tumors and tumor-draining lymph nodes 7 , and to increase the mouse serum protein levels of several of these cytokines, including G-CSF and CXCL1/KC 7,8 . Bone marrow-derived cells appear to be key mediators of the antitumor immune response, as Val-boroPro has been reported to induce cytokines from bone marrow stromal cells 9 and from co-cultures of THP-1 macrophages and fibroblasts in vitro 9,10 , and clodronate depletion of phagocytic cells significantly reduces Val-boroPro’s antitumor activity in vivo 8 . However, the molecular and cellular mechanisms controlling Val-boroPro-induced immune activation, including the key serine protease target(s), signaling pathways, and the cell types affected by Val-boroPro, have not been established. …”Section: Introductionmentioningconfidence: 99%See 1 more Smart Citation

DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis

Okondo1, Johnson2, Sridharan3 et al. 2016Nat Chem Biol280232992Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.