Abstract:REATMENT OF LEAD TOXICITYwith chelation was first reported with EDTA in the early 1950s. 1 Apparent success in reducing metastatic calcium deposits 2 led Clarke et al 3 in 1956 to treat angina patients with EDTA, and others to use chelation for various forms of atherosclerotic disease. [4][5][6] Chelation therapy evolved to constitute infusions of vitamins and disodium EDTA, a drug that binds divalent and some trivalent cations, including calcium, magnesium, lead, cadmium, zinc, iron, aluminum, and copper, fac… Show more