Expression and distribution patterns of Mas-related gene receptor subtypes A–H in the mouse intestine: inflammation-induced changes (VSports在线直播)

"V体育官网" Mas and Its Related G Protein–Coupled Receptors, Mrgprs

Bäder1, Alenina2, Andrade‐Navarro3 et al. 2014Pharmacological Reviews16631480Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. “…In contrast, rMrgprX1 was detected by immunohistochemistry in skin mast cells (Hager et al, 2008). mMrgprB10 was found in mucosal mast cells in mouse intestine in inflammatory conditions (Avula et al, 2013). The presence of other Mrgprs (A and E-H) was not tested in mouse mast cells other than in one study showing the absence of mMrgprA3 transcripts (Liu et al, 2009). …”Section: Expression Of Mas-related G Protein-coupled Receptors In mentioningconfidence: 96%“…All members are expressed there and in the trigeminal ganglia in small diameter nociceptive neurons in mice; however, Mas, as well as MrgprF, G, and H are expressed at low levels (Cox et al, 2008;Costa et al, 2012;Avula et al, 2013;Cao et al, 2013a). mMrgprexpressing neurons are nonpeptidergic, characterized by the presence of immunoreactivity for the Griffonia simplicifolia lectin IB4 and the glial-cell line-derived neurotrophic factor coreceptor c-Ret and the absence of transient receptor potential vanilloid 1 (TRPV1), substance P, and, in most but not all cases, of calcitonin gene-related peptide (CGRP) (Dong et al, 2001;Han et al, 2013) (Fig. …”Section: B Expression Of Mas-related G Protein-coupled Receptors In mentioningconfidence: 99%“…However, the localization of rMrgprA expression in the vasculature and in the collecting duct of the kidney was recently reported in detail, and an inhibition of vasopressin signaling by rMrgprA was postulated (Kishore et al, 2013). One group has systematically analyzed the expression of all Mrgprs in mouse intestine (Avula et al, 2011(Avula et al, , 2013. With a few exceptions, they are all expressed on different types of enteric neurons in varying levels; however, the function of Mrgprs in these cells is elusive. …”Section: Expression Of Mas-related G Protein-coupled Receptors In mentioningconfidence: 99%“…With a few exceptions, they are all expressed on different types of enteric neurons in varying levels; however, the function of Mrgprs in these cells is elusive. Under normal conditions, mMrgprA4 and mMrgprA7 are most highly expressed, and in inflammation, mMrgprA2, mMrgprA5, mMrgprB2, mMrgprB10, mMrgprX1, and mMrgprD get upregulated, which is partly due to the invasion of mast cells (mMrgprB10) (Avula et al, 2013). …”Section: Expression Of Mas-related G Protein-coupled Receptors In mentioningconfidence: 99%See 2 more Smart Citations

Mas and Its Related G Protein–Coupled Receptors, Mrgprs

Bäder1, Alenina2, Andrade‐Navarro3 et al. 2014Pharmacological Reviews16631480Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD) VSports app下载. Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. “…Although the fibers expressing this novel RAS-related receptor are not present in the bone marrow [144], these sensory fibers could be important in other peripheral organs and even the vasculature. Recently, MrgD receptors have been found to regulate mast cell activation during intestinal inflammation [156, 157]. Therefore, it is possible that there is a direct link between the peripheral RAS communicating to the brain through afferent nerves and the inflammatory response in hypertension. …”Section: Possible Role Of Sensory Inputmentioningconfidence: 99%

Dysfunctional Brain-bone Marrow Communication: A Paradigm Shift in the Pathophysiology of Hypertension

Santisteban1, Zubcevic2, Baekey3 et al. 2013Curr Hypertens Rep330300Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract

Neuropeptide AF Induces Piecemeal Degranulation in Murine Mucosal Mast Cells: A New Mediator in Neuro‐Immune Communication in the Intestinal Lamina Propria?

Abdellah1, Remoortel2, Mohey‐Elsaeed3 et al. 2018The Anatomical RecordSelf Cite9060Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.