Microbial Translocation in the Pathogenesis of HIV Infection and AIDS

Neisseria gonorrhoeae-derived heptose elicits an innate immune response and drives HIV-1 expression

Malott1, Keller2, Gaudet3 et al. 2013Proc. Natl. Acad. Sci. U. S. A. 561530Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…This effect would be akin to the translocation of microbial products from the gut of HIV patients as the result of HIV-induced enteropathy (51). The systemic immunomodulatory effects of these microbial components contribute to chronic immune activation and disease progression in people living with HIV (51). …”Section: Discussionmentioningconfidence: 99%“…This effect would be akin to the translocation of microbial products from the gut of HIV patients as the result of HIV-induced enteropathy (51). The systemic immunomodulatory effects of these microbial components contribute to chronic immune activation and disease progression in people living with HIV (51). In this context, it also is enticing to speculate that this persistent innate activation could provide the impetus to initiate the uncontrolled inflammation that is the hallmark of gonorrhea, suggesting that Ng has a curious lifestyle finely balanced between asymptomatic colonization and inflammatory disease. …”Section: Discussionmentioningconfidence: 99%

Neisseria gonorrhoeae-derived heptose elicits an innate immune response and drives HIV-1 expression (VSports注册入口)

Malott1, Keller2, Gaudet3 et al. 2013Proc. Natl. Acad. Sci. U. S. A VSports app下载. 561530Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…These impairments include mucosal depletion of CD4 + T cells, local hyperactivation/inflammation, exhaustion of intestinal macrophage phagocytic function, and an altered gut microbiome (reviewed in Ref. 3). As a result of these events, microbial products are translocated from the gastrointestinal tract to the systemic circulation, and this mechanism has been proposed as a major driver of the chronic immune activation associated with disease progression (4). …”mentioningconfidence: 99%

Stable CD4 Expression and Local Immune Activation in the Ectocervical Mucosa of HIV-Infected Women

Hirbod1, Kimani2, Tjernlund3 et al. 2013The Journal of Immunology224260Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Ils se caracté-risent par l'expression du récepteur CCR6 (C-C chemokine receptor type 6) et de l'intégrine 4 7, ce qui les rend sensibles à l'infection par le VIH [23]. Leur déplétion favorise le passage de bactéries digestives dans la muqueuse, stimulant ainsi en continu l'immunité innée et adaptative locale [24]. Il en résulte à la fois l'épuisement des fonctions phagocytaires des macrophages muqueux, et celui des lymphocytes T du GALT qui deviennent incapables de remplir leur fonction de cytotoxicité [24,25]. …”Section: Le Galt Premier Réservoir Et Sanctuaire Anatomique Pour Le unclassified

Infection par le virus de l’immunodéficience humaine

Vergnon-Miszczycha1, Lucht2, Roblin3 et al. 2015Med Sci (Paris)3010Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Scite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 3 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.