Metallostasis in Alzheimer's disease

Clioquinol promotes the degradation of metal-dependent amyloid-β (Aβ) oligomers to restore endocytosis and ameliorate Aβ toxicity

Matlack1, Tardiff2, Narayan3 et al. 2014Proc. Natl. Acad. Sci. U. S. A. 16551540Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Although multiple metal-related Aβ pathologies and modes of action for CQ-and PBT2-have been described and postulated (17,18,28), our data suggest a mechanism of action in the yeast model that is not ionophore based (18). Rather, CQ promoted the degradation of metal-dependent Aβ oligomers within the secretory and endosomal compartments. …”Section: Discussionmentioningconfidence: 59%“…However, it is important to note that multiple mechanisms likely operate on the longer timescales of Aβ accumulation in mouse models and in human disease. For example, accumulation of transition metals in extracellular Aβ plaques formed late in disease can limit intracellular metal availability (28). CQ can dissolve plaques that have formed in late stages of disease (in both mice and humans) (17) and liberate trapped metals. …”Section: Discussionmentioningconfidence: 99%“…Metal ions, including copper, iron, and zinc, bind to Aβ both in vitro and within Aβ plaques from the brains of AD patients (28,29). In in vitro assembly reactions with Aβ, the addition of copper favors the formation of nonfibrillar, amorphous aggregates (29) and oligomers (30,31) that are more toxic to cells than amyloid fibers of Aβ (18,(30)(31)(32). …”Section: Screen For Compounds That Rescue Aβ Toxicity In Yeastmentioningconfidence: 99%See 1 more Smart Citation

V体育安卓版 - Clioquinol promotes the degradation of metal-dependent amyloid-β (Aβ) oligomers to restore endocytosis and ameliorate Aβ toxicity

Matlack1, Tardiff2, Narayan3 et al. 2014Proc. Natl. Acad. Sci. U. S. A. 16551540Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Our data demonstrated that the production of cytokines, including IFN-g and TNF-a, is induced by C. neoformans infection in the lung tissues but not in the brain. Most importantly, Cu accumulation is often associated with neurodegenerative disease 49 . In conclusion, our study highlights the reciprocal roles of C. neoformans Cu transporters in the host, and underscores the importance of analysing host niches during the investigation of Cryptococcus pathogenicity. …”Section: Discussionmentioningconfidence: 99%

"V体育安卓版" Reciprocal functions of Cryptococcus neoformans copper homeostasis machinery during pulmonary infection and meningoencephalitis

Sun1, Ju2, Gao3 et al. 2014Nat Commun9281271Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD) VSports app下载. Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. “…There is dysregulation of the homeostatic mechanisms of iron, copper, and zinc in AD, and these metals can bind pathologically to Aβ and tau proteins [11]. We, and others, have integrated the metal hypothesis of AD with the amyloid cascade hypothesis, and preclinical and clinical data demonstrate that metals might be a more tractable drug target to address underlying disease mechanisms of AD. …”Section: Introductionmentioningconfidence: 99%

Biometals and Their Therapeutic Implications in Alzheimer's Disease (VSports手机版)

Ayton1, Lei2, Bush3 2015NeurotherapeuticsSelf Cite11711170Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 3 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.