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. 1998 Dec 11;441(1):106-10.
doi: 10.1016/s0014-5793(98)01514-2.

Positive feedback regulation of type I IFN genes by the IFN-inducible transcription factor IRF-7 (V体育安卓版)

M Sato  1 , N Hata, M Asagiri, T Nakaya, T Taniguchi, N Tanaka
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Positive feedback regulation of type I IFN genes by the IFN-inducible transcription factor IRF-7

M Sato et al. FEBS Lett. .
Free article

Abstract

The interferon regulatory factor (IRF) family of transcription factors regulate the interferon (IFN) system, among which IRF-3 is involved in the virus-induced IFN-beta gene expression. Here we show that another member IRF-7 is critical for the IFN-alpha gene induction. Unlike the IRF-3 gene, the IRF-7 gene is induced by IFNs through activation of the ISGF3 transcription factor, and IRF-7 undergoes virus-induced nuclear translocation. In cells lacking p48, an essential component of IFN stimulated gene factor 3 (ISGF3), ectopic expression of IRF-7 but not IRF-3 can rescue the deficiency to induce IFN-alpha genes VSports手机版. These results indicate that IRF-7 is a key factor in the positive feedback regulation of IFN-alpha/beta production. .

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