"V体育安卓版" Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official VSports app下载. Federal government websites often end in . gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely V体育官网. .

. 1998 Oct 30;95(3):379-91.
doi: 10.1016/s0092-8674(00)81769-9.

"V体育官网" Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4

J Nichols  1 , B Zevnik, K Anastassiadis, H Niwa, D Klewe-Nebenius, I Chambers, H Schöler, A Smith
Affiliations
Free article

Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4

J Nichols et al. Cell. .
Free article

Abstract

Oct4 is a mammalian POU transcription factor expressed by early embryo cells and germ cells VSports手机版. We report that the activity of Oct4 is essential for the identity of the pluripotential founder cell population in the mammalian embryo. Oct4-deficient embryos develop to the blastocyst stage, but the inner cell mass cells are not pluripotent. Instead, they are restricted to differentiation along the extraembryonic trophoblast lineage. Furthermore, in the absence of a true inner cell mass, trophoblast proliferation is not maintained in Oct4-/- embryos. Expansion of trophoblast precursors is restored, however, by an Oct4 target gene product, fibroblast growth factor-4. Therefore, Oct4 also determines paracrine growth factor signaling from stem cells to the trophectoderm. .

PubMed Disclaimer

"V体育ios版" Publication types

MeSH terms