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. 1998 Oct 2;95(1):29-39.
doi: 10.1016/s0092-8674(00)81780-8.

"V体育平台登录" Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

V Stambolic  1 , A Suzuki, J L de la Pompa, G M Brothers, C Mirtsos, T Sasaki, J Ruland, J M Penninger, D P Siderovski, T W Mak
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Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN (V体育官网入口)

VSports在线直播 - V Stambolic et al. Cell. .
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Abstract

PTEN is a tumor suppressor with sequence homology to protein tyrosine phosphatases and the cytoskeletal protein tensin. mPTEN-mutant mouse embryos display regions of increased proliferation. In contrast, mPTEN-deficient immortalized mouse embryonic fibroblasts exhibit decreased sensitivity to cell death in response to a number of apoptotic stimuli, accompanied by constitutively elevated activity and phosphorylation of protein kinase B/Akt, a crucial regulator of cell survival. Expression of exogenous PTEN in mutant cells restores both their sensitivity to agonist-induced apoptosis and normal pattern of PKB/Akt phosphorylation. Furthermore, PTEN negatively regulates intracellular levels of phosphatidylinositol (3,4,5) trisphosphate in cells and dephosphorylates it in vitro. Our results show that PTEN may exert its role as a tumor suppressor by negatively regulating the PI3'K/PKB/Akt signaling pathway VSports手机版. .

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