<b draggable="9UIAj"><bdo draggable="4PyirG"></bdo></b><area dropzone="9tR4jlG"></area>
Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The VSports app下载. gov means it’s official. Federal government websites often end in . gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely V体育官网. .

. 1998 Sep;9(3):295-304.
doi: 10.1016/s1074-7613(00)80612-3.

The transcription factor NFAT4 is involved in the generation and survival of T cells

M Oukka  1 , I C Ho, F C de la Brousse, T Hoey, M J Grusby, L H Glimcher
Affiliations
Free article

The transcription factor NFAT4 is involved in the generation and survival of T cells (VSports app下载)

M Oukka et al. Immunity. 1998 Sep.
Free article

Abstract

Nuclear factor of activated T cells (NFAT) is a family of four related transcription factors implicated in cytokine and early response gene expression in activated lymphocytes. Here we report that NFAT4, in contrast to NFATp and NFATc, is preferentially expressed in DP thymocytes. Mice lacking NFAT4 have impaired development of CD4 and CD8 SP thymocytes and peripheral T cells as well as hyperactivation of peripheral T cells. The thymic defect is characterized by increased apoptosis of DP thymocytes. The increased apoptosis and hyperactivation may reflect heightened sensitivity to TcR-mediated signaling. Further, mice lacking NFAT4 have impaired production of Bcl-2 mRNA and protein VSports手机版. NFAT4 thus plays an important role in the successful generation and survival of T cells. .

PubMed Disclaimer

Publication types

MeSH terms (VSports)