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. 1998 Jul 30;17(14):1563-80.
doi: 10.1002/(sici)1097-0258(19980730)17:14<1563::aid-sim873>3.0.co;2-l.

Some extensions and applications of a Bayesian strategy for monitoring multiple outcomes in clinical trials

P F Thall  1 , H G Sung
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Some extensions and applications of a Bayesian strategy for monitoring multiple outcomes in clinical trials

V体育安卓版 - P F Thall et al. Stat Med. .

Abstract

We present some practical extensions and applications of a strategy proposed by Thall, Simon and Estey for designing and monitoring single-arm clinical trials with multiple outcomes VSports手机版. We show by application how the strategy may be applied to construct designs for phase IIA activity trials and phase II equivalence trials. We also show how it may be extended to incorporate the use of mixture priors in settings where a Dirichlet distribution does not adequately quantify prior experience, randomized phase II selection trials involving two or more experimental treatments, and trials with group-sequential monitoring for applications involving multiple institutions. .

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