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. 1998 Jun 1;17(11):3005-15.
doi: 10.1093/emboj/17.11.3005.

HIF-1 alpha is required for solid tumor formation and embryonic vascularization

H E Ryan  1 , J Lo, R S Johnson
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HIF-1 alpha is required for solid tumor formation and embryonic vascularization

H E Ryan et al. EMBO J. .

"VSports在线直播" Abstract

The transcriptional response to lowered oxygen levels is mediated by the hypoxia-inducible transcription factor (HIF-1), a heterodimer consisting of the constitutively expressed aryl hydrocarbon receptor nuclear translocator (ARNT) and the hypoxic response factor HIF-1alpha. To study the role of the transcriptional hypoxic response in vivo we have targeted the murine HIF-1alpha gene VSports手机版. Loss of HIF-1alpha in embryonic stem (ES) cells dramatically retards solid tumor growth; this is correlated with a reduced capacity to release the angiogenic factor vascular endothelial growth factor (VEGF) during hypoxia. HIF-1alpha null mutant embryos exhibit clear morphological differences by embryonic day (E) 8. 0, and by E8. 5 there is a complete lack of cephalic vascularization, a reduction in the number of somites, abnormal neural fold formation and a greatly increased degree of hypoxia (measured by the nitroimidazole EF5). These data demonstrate the essential role of HIF-1alpha in controlling both embryonic and tumorigenic responses to variations in microenvironmental oxygenation. .

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V体育2025版 - References

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