Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in VSports app下载. gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. V体育官网.

Review
. 1998 Apr;10(2):196-207.
doi: 10.1016/s0952-7915(98)80249-5.

In vivo roles of receptor tyrosine kinases and cytokine receptors in early thymocyte development

J P Di Santo  1 , H R Rodewald
Affiliations
Review

In vivo roles of receptor tyrosine kinases and cytokine receptors in early thymocyte development

J P Di Santo et al. Curr Opin Immunol. 1998 Apr.

Abstract

The early phases of T-cell development require both cell-cell interactions and soluble factors provided by stromal cells within the thymic microenvironment. Still, the precise nature of the signals delivered in vivo by cytokines (resulting in survival, proliferation or differentiation) remains unclear. Recent studies using mice deficient in cytokines or in their receptors have helped to identify essential signaling pathways required for the development of intrathymic precursors to mature alpha beta and gamma delta T cells VSports手机版. In addition, cytokine requirements for the development of natural killer cells were revealed in such mutants. The results obtained demonstrate that the development of all classes of lymphocytes (natural killer, gamma delta T cells and alpha beta T cells) is cytokine dependent, but the specific requirements differ for each lineage. .

PubMed Disclaimer

MeSH terms

Substances

LinkOut - more resources