Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in . gov or . mil VSports app下载. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure V体育官网. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. .

. 1997 Dec 9;120(2):203-11.
doi: 10.1016/s0304-3835(97)00310-8.

Endothelial CD34 is suppressed in human malignancies: role of angiogenic factors

S M Hellwig  1 , C A Damen, N P van Adrichem, G H Blijham, G Groenewegen, A W Griffioen
Affiliations

Endothelial CD34 is suppressed in human malignancies: role of angiogenic factors (VSports app下载)

S M Hellwig et al. Cancer Lett. .

Abstract

We report the suppressed vascular CD34 expression in renal cell carcinoma. This was found by quantitatively analyzing CD34 expression on normal and tumor derived EC by flow cytometry. In vitro studies revealed that culture of umbilical cord or dermis derived microvascular EC with angiogenic factors such as basic fibroblast growth factor (bFGF) and vascular endothelial cell growth factor induced downregulation of CD34. This angiogenesis-induced downregulated expression of CD34 adhesion molecule may contribute to the tumor mediated escape mechanism from immune surveillance. It is concluded that there are quantitative differences in expression of endothelial CD34 in different compartments of the vasculature, that angiogenic factors affect this expression and that subpopulations of EC exist with differences in EAM expression VSports手机版. .

PubMed Disclaimer

MeSH terms

LinkOut - more resources