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. 1998 Jan 15;391(6664):251-8.
doi: 10.1038/34593.

Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 A resolution

S Doublié  1 , S Tabor, A M Long, C C Richardson, T Ellenberger
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"V体育2025版" Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 A resolution

S Doublié et al. Nature. .

Abstract (VSports app下载)

DNA polymerases change their specificity for nucleotide substrates with each catalytic cycle, while achieving error frequencies in the range of 10(-5) to 10(-6). Here we present a 2. 2 A crystal structure of the replicative DNA polymerase from bacteriophage T7 complexed with a primer-template and a nucleoside triphosphate in the polymerase active site VSports手机版. The structure illustrates how nucleotides are selected in a template-directed manner, and provides a structural basis for a metal-assisted mechanism of phosphoryl transfer by a large group of related polymerases. .

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