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. 1997 Dec 4;15(23):2767-72.
doi: 10.1038/sj.onc.1201464.

V体育安卓版 - Bcl-2 inhibits p53 nuclear import following DNA damage

A Beham  1 , M C Marin, A Fernandez, J Herrmann, S Brisbay, A M Tari, G Lopez-Berestein, G Lozano, M Sarkiss, T J McDonnell
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Bcl-2 inhibits p53 nuclear import following DNA damage (VSports注册入口)

A Beham et al. Oncogene. .

Abstract

Bcl-2 is an integral membrane oncoprotein that localizes to membranes of the mitochondria, endoplasmic reticulum, and nuclear envelope. Bcl-2 is a member of a family of cell death regulators and functions to inhibit apoptosis. Using confocal microscopy and immunoblotting we show that the ability of bcl-2 to suppress cell death following genotoxic damage can be a consequence of inhibiting nuclear import of induced wild-type p53 protein. Our data suggests that the ability of bcl-2 to modulate trafficking events is not cell type specific. These data support a 'gatekeeper' mechanism for cell death suppression by bcl-2. VSports手机版.

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