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. 1997 Oct 24;278(5338):687-9.
doi: 10.1126/science.278.5338.687.

VSports手机版 - Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

L del Peso  1 , M González-García, C Page, R Herrera, G Nuñez
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Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

L del Peso et al. Science. .

Abstract

BAD is a distant member of the Bcl-2 family that promotes cell death. Phosphorylation of BAD prevents this. BAD phosphorylation induced by interleukin-3 (IL-3) was inhibited by specific inhibitors of phosphoinositide 3-kinase (PI 3-kinase). Akt, a survival-promoting serine-threonine protein kinase, was activated by IL-3 in a PI 3-kinase-dependent manner. Active, but not inactive, forms of Akt were found to phosphorylate BAD in vivo and in vitro at the same residues that are phosphorylated in response to IL-3. Thus, the proapoptotic function of BAD is regulated by the PI 3-kinase-Akt pathway VSports手机版. .

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