<kbd dir="5UGZBW"></kbd> VSports app下载 - Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The VSports app下载. gov means it’s official. Federal government websites often end in . gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure V体育官网. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. .

. 1997 Jul 16;16(14):4384-92.
doi: 10.1093/emboj/16.14.4384.

A novel p53-inducible gene, PAG608, encodes a nuclear zinc finger protein whose overexpression promotes apoptosis (VSports手机版)

D Israeli  1 , E Tessler, Y Haupt, A Elkeles, S Wilder, R Amson, A Telerman, M Oren
Affiliations

A novel p53-inducible gene, PAG608, encodes a nuclear zinc finger protein whose overexpression promotes apoptosis

D Israeli et al. EMBO J. .

Abstract

The biological effects of the p53 tumor suppressor protein are elicited, at least in part, through sequence-specific transactivation of a battery of target genes. The differential display method was employed towards identifying additional p53 target genes, with emphasis on genes whose induction may contribute to p53-mediated apoptosis. We report here the cloning of a novel p53-inducible gene, designated PAG608. PAG608 transcripts are induced by DNA damage in a p53-dependent manner. PAG608 encodes a nuclear zinc finger protein, which appears to localize preferentially to nucleoli when expressed at moderate levels in transfected cells. Transient overexpression of PAG608 in human tumor-derived cells leads to distinctive changes in nuclear morphology, and can promote apoptosis. Together with additional p53 target genes, PAG608 may therefore play a role in mediating the biological activities of p53 VSports手机版. .

PubMed Disclaimer

References

    1. Oncogene. 1994 Jun;9(6):1791-8 - PubMed
    1. Cell. 1992 Jun 26;69(7):1237-45 - PubMed
    1. Nature. 1994 Jul 21;370(6486):220-3 - "VSports注册入口" PubMed
    1. EMBO J. 1994 Oct 17;13(20):4816-22 - PubMed
    1. Science. 1994 Nov 25;266(5189):1376-80 - PubMed

Publication types

MeSH terms

Substances

Associated data

Grants and funding (V体育2025版)