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. 1997 Jul 25;90(2):315-23.
doi: 10.1016/s0092-8674(00)80339-6.

VSports在线直播 - The regulation of anoikis: MEKK-1 activation requires cleavage by caspases

M H Cardone  1 , G S Salvesen, C Widmann, G Johnson, S M Frisch
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The regulation of anoikis: MEKK-1 activation requires cleavage by caspases

M H Cardone et al. Cell. .
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"V体育2025版" Abstract

Certain cell types undergo apoptosis when they lose integrin-mediated contacts with the extracellular matrix ("anoikis"). The Jun N-terminal kinase (JNK) pathway is activated in and promotes anoikis. This activation requires caspase activity. We presently report that a DEVD motif-specific caspase that cleaves MEKK-1 specifically is activated when cells lose matrix contact VSports手机版. This cleavage is required for the activation of the kinase activity. When overexpressed, the MEKK-1 cleavage product stimulates apoptosis; the wild-type, full-length MEKK-1 sensitizes cells to anoikis; and a cleavage-resistant mutant of MEKK-1 partially protects cells against anoikis. The cleavage-resistant or kinase-inactive mutants also prevent caspase-7 from being activated completely. Thus, caspases can induce apoptosis by activating MEKK-1, which in turn activates more caspase activity, comprising a positive feedback loop. .

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