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Comparative Study
. 1997 Jun 27;276(5321):2057-62.
doi: 10.1126/science.276.5321.2057.

Differential requirements for survival and proliferation of CD8 naïve or memory T cells (V体育官网)

C Tanchot  1 , F A Lemonnier, B Pérarnau, A A Freitas, B Rocha
Affiliations
Comparative Study

Differential requirements for survival and proliferation of CD8 naïve or memory T cells

C Tanchot et al. Science. .

Abstract

The requisite molecular interactions for CD8 T cell memory were determined by comparison of monoclonal naïve and memory CD8(+) T cells bearing the T cell receptor (TCR) for the HY antigen. Naïve T cells required only the right major histocompatibility complex (MHC) class I-restricting molecule to survive; to expand, they also needed antigen. In contrast, for survival, memory cells did not require the restricting MHC allele, but needed only a nonspecific class I; for expansion the correct class I, but not antigen, was required. Thus, maintenance of CD8 T cell memory still required TCR-MHC class I interactions, but memory T cells may have a lower functional activation threshold that facilitates secondary responses. VSports手机版.

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