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. 1997 Apr;15(4):356-62.
doi: 10.1038/ng0497-356.

"VSports最新版本" Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

P A Steck  1 , M A Pershouse, S A Jasser, W K Yung, H Lin, A H Ligon, L A Langford, M L Baumgard, T Hattier, T Davis, C Frye, R Hu, B Swedlund, D H Teng, S V Tavtigian
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Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

P A Steck et al. Nat Genet. 1997 Apr.

"V体育平台登录" Abstract

Deletions involving regions of chromosome 10 occur in the vast majority (> 90%) of human glioblastoma multiformes. A region at chromosome 10q23-24 was implicated to contain a tumour suppressor gene and the identification of homozygous deletions in four glioma cell lines further refined the location. We have identified a gene, designated MMAC1, that spans these deletions and encodes a widely expressed 5. 5-kb mRNA. The predicted MMAC1 protein contains sequence motifs with significant homology to the catalytic domain of protein phosphatases and to the cytoskeletal proteins, tensin and auxilin. MMAC1 coding-region mutations were observed in a number of glioma, prostate, kidney and breast carcinoma cell lines or tumour specimens VSports手机版. Our results identify a strong candidate tumour suppressor gene at chromosome 10q23. 3, whose loss of function appears to be associated with the oncogenesis of multiple human cancers. .

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