"VSports最新版本" Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in VSports app下载. gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. V体育官网.

. 1997 Apr 4;276(5309):111-3.
doi: 10.1126/science.276.5309.111.

The receptor for the cytotoxic ligand TRAIL

G Pan  1 , K O'Rourke, A M Chinnaiyan, R Gentz, R Ebner, J Ni, V M Dixit
Affiliations

VSports app下载 - The receptor for the cytotoxic ligand TRAIL

G Pan et al. Science. .

Abstract

TRAIL (also known as Apo-2L) is a member of the tumor necrosis factor (TNF) ligand family that rapidly induces apoptosis in a variety of transformed cell lines. The human receptor for TRAIL was found to be an undescribed member of the TNF-receptor family (designated death receptor-4, DR4) that contains a cytoplasmic "death domain" capable of engaging the cell suicide apparatus but not the nuclear factor kappa B pathway in the system studied VSports手机版. Unlike Fas, TNFR-1, and DR3, DR4 could not use FADD to transmit the death signal, suggesting the use of distinct proximal signaling machinery. Thus, the DR4-TRAIL axis defines another receptor-ligand pair involved in regulating cell suicide and tissue homeostasis. .

PubMed Disclaimer

Publication types

MeSH terms

Substances

Associated data

LinkOut - more resources