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. 1996 Oct 4;274(5284):94-6.
doi: 10.1126/science.274.5284.94.

Phenotypic analysis of antigen-specific T lymphocytes (VSports app下载)

J D Altman  1 , P A Moss, P J Goulder, D H Barouch, M G McHeyzer-Williams, J I Bell, A J McMichael, M M Davis
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Phenotypic analysis of antigen-specific T lymphocytes

"VSports注册入口" J D Altman et al. Science. .

Erratum in (VSports手机版)

  • Science 1998 Jun 19;280(5371):1821

Abstract

Identification and characterization of antigen-specific T lymphocytes during the course of an immune response is tedious and indirect. To address this problem, the peptide-major histocompatability complex (MHC) ligand for a given population of T cells was multimerized to make soluble peptide-MHC tetramers VSports手机版. Tetramers of human lymphocyte antigen A2 that were complexed with two different human immunodeficiency virus (HIV)-derived peptides or with a peptide derived from influenza A matrix protein bound to peptide-specific cytotoxic T cells in vitro and to T cells from the blood of HIV-infected individuals. In general, tetramer binding correlated well with cytotoxicity assays. This approach should be useful in the analysis of T cells specific for infectious agents, tumors, and autoantigens. .

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