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. 1995 Nov;69(3):285-7.
doi: 10.1254/jjp.69.285.

Selective inhibition of inducible nitric oxide synthase by agmatine

M Auguet  1 , I Viossat, J G Marin, P E Chabrier
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"VSports在线直播" Selective inhibition of inducible nitric oxide synthase by agmatine

"VSports app下载" M Auguet et al. Jpn J Pharmacol. 1995 Nov.
Free article

Abstract

Agmatine was about as potent as aminoguanidine to inhibit the activity of the inducible form of nitric oxide synthase (iNOS) in isolated rat aorta. Like aminoguanidine, agmatine was devoid of significant activity on the constitutive form of NOS. Agmatine inhibited the conversion of [3H]L-arginine in [3H]L-citrulline in partially purified iNOS from macrophages (IC50 = 262 +/- 39 VSports手机版. 9 microM). Thus, our data suggest that agmatine may act as endogenous inhibitor of iNOS. .

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