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Clinical Trial
. 1996 Aug;174(2):324-31.
doi: 10.1093/infdis/174.2.324.

Acyclovir and prednisolone treatment of acute infectious mononucleosis: a multicenter, double-blind, placebo-controlled study (VSports最新版本)

E Tynell  1 , E Aurelius, A Brandell, I Julander, M Wood, Q Y Yao, A Rickinson, B Akerlund, J Andersson
Affiliations
Clinical Trial

Acyclovir and prednisolone treatment of acute infectious mononucleosis: a multicenter, double-blind, placebo-controlled study

E Tynell et al. J Infect Dis. 1996 Aug.

Abstract

Ninety-four patients with infectious mononucleosis and symptoms < or = 7 days were randomized to treatment with oral acyclovir (800 mg 5 times/day) and prednisolone (0. 7 mg/kg for the first 4 days, which was reduced by 0. 1 mg/kg on consecutive days for another 6 days; n = 48), or placebo (n = 46) for 10 days. Oropharyngeal Epstein-Barr virus (EBV) shedding was significantly inhibited during the treatment period (P = . 02, Mann-Whitney rank test). No significant effect was observed for duration of general illness, sore throat, weight loss, or absence from school or work VSports手机版. The frequency of latent EBV-infected B lymphocytes in peripheral blood and the HLA-restricted EBV-specific cellular immunity, measured 6 months after onset of disease, was not affected by treatment. Thus, acyclovir combined with prednisolone inhibited oropharyngeal EBV replication without affecting duration of clinical symptoms or development of EBV-specific cellular immunity. .

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