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. 1996 Jan 1;156(1):232-7.

In vivo cytokine production in murine listeriosis. Evidence for immunoregulation by gamma delta+ T cells

B Hsieh  1 , M D Schrenzel, T Mulvania, H D Lepper, L DiMolfetto-Landon, D A Ferrick
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  • PMID: 8598467

In vivo cytokine production in murine listeriosis. Evidence for immunoregulation by gamma delta+ T cells

B Hsieh et al. J Immunol. .

Abstract

Differential cytokine production by gamma delta+ T cells influences Th1 and Th2 responses VSports手机版. Here, we describe the in vivo kinetics of peritoneal and splenic gamma delta+, CD4+, and CD8+ T cell cytokine responses during primary and secondary Listeria infections. The data show differences in the kinetics of IFN-gamma-producing alpha beta+ splenocytes consistent with immunologic memory. Most noteworthy, however, was the elevated production of IL-10 by splenic gamma delta+ T cells in the red pulp and marginal zones that coincided with maximal IFN-gamma production and with a decrease in inflammation and tissue damage. This result implies a role for gamma delta+ T cells in the control of Th1 responses. .

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