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. 1994 Jun;44(6):1083-6.
doi: 10.1212/wnl.44.6.1083.

Turcot's syndrome: evidence for linkage to the adenomatous polyposis coli (APC) locus (V体育平台登录)

D M Lasser  1 , D C DeVivo, J Garvin, K C Wilhelmsen
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Turcot's syndrome: evidence for linkage to the adenomatous polyposis coli (APC) locus

D M Lasser et al. Neurology. 1994 Jun.

Abstract

Objective: To investigate the possibility that neuroepithelial tumors in Turcot's syndrome are caused by pleiotropic mutations in the gene for adenomatous polyposis coli (APC), a tumor-suppressor gene implicated in colonic cancer. VSports手机版.

Methods: We studied the inheritance patterns of genetic markers for the chromosome 5q21 region in 12 members of a Turcot's syndrome kindred with five affected members. We performed linkage analysis to detect linkage between the disease phenotype and DNA markers V体育安卓版. .

Results: Marker D5S346, located 30 to 70 kilobases from the APC locus, showed evidence highly suggestive of linkage to the disease phenotype (lod score = 1. 92) V体育ios版. .

Conclusions: The data provide evidence that the tumor-suppressor gene implicated in APC and sporadic colon cancers may also cause malignant neuroepithelial tumors in Turcot's syndrome. VSports最新版本.

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