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. 1993 Jun 25;260(5116):1942-6.
doi: 10.1126/science.8100367.

Induction of type I diabetes by interferon-alpha in transgenic mice

T A Stewart  1 , B Hultgren, X Huang, S Pitts-Meek, J Hully, N J MacLachlan
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Induction of type I diabetes by interferon-alpha in transgenic mice

"V体育官网入口" T A Stewart et al. Science. .

Abstract

Type I diabetes is an autoimmune disease involving an interaction between an epigenetic event (possibly a viral infection), the pancreatic beta cells, and the immune system in a genetically susceptible host. The possibility that the type I interferons could mediate this interaction was tested with transgenic mice in which the insulin-producing beta cells expressed an interferon-alpha. These mice developed a hypoinsulinemic diabetes associated with a mixed inflammation centered on the islets. The inflammation and the diabetes were prevented with a neutralizing antibody to the interferon-alpha. Thus, the expression of interferon-alpha by the beta cells could be causal in the development of type I diabetes, which suggests a therapeutic approach to this disease. VSports手机版.

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