"V体育2025版" Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in . gov or . mil VSports app下载. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. V体育官网.

. 1994 Sep 15;371(6494):257-61.
doi: 10.1038/371257a0.

p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

G J Hannon  1 , D Beach
Affiliations

"V体育官网" p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

"VSports在线直播" G J Hannon et al. Nature. .

Abstract

Transforming growth factor-beta (TGF-beta) inhibits cell proliferation by inducing a G1-phase cell cycle arrest. Normal progression through G1 is promoted by the activity of the cyclin-dependent protein kinases CDK4 and CDK6 (ref. 2), which are inhibited by the protein p16INK4. We have isolated a new member of the p16INK4 family, p15INK4B. p15 expression is induced approximately 30-fold in human keratinocytes by treatment with TGF-beta, suggesting that p15 may act as an effector of TGF-beta-mediated cell cycle arrest VSports手机版. The gene encoding p15 is located on chromosome 9 adjacent to the p16 gene at a frequent site of chromosomal abnormality in human tumours (9p21). .

PubMed Disclaimer

Comment in (V体育平台登录)

V体育官网 - Publication types

MeSH terms

Substances

Associated data