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Comparative Study
. 1994 Jul 15;13(14):3286-95.
doi: 10.1002/j.1460-2075.1994.tb06630.x.

c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines

E A Harrington  1 , M R Bennett, A Fanidi, G I Evan
Affiliations
Comparative Study

c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines (VSports)

E A Harrington et al. EMBO J. .

Abstract

We have investigated the mechanism by which deregulated expression of c-Myc induces death by apoptosis in serum-deprived fibroblasts VSports手机版. We demonstrate that Myc-induced apoptosis in low serum is inhibited by a restricted group of cytokines, principally the insulin-like growth factors and PDGF. Cytokine-mediated protection from apoptosis is not linked to the cytokines' abilities to promote growth. Protection from apoptosis is evident in the post-commitment (mitogen-independent) S/G2/M phases of the cell cycle and also in cells that are profoundly blocked in cell cycle progression by drugs. Moreover, IGF-I inhibition of apoptosis occurs in the absence of protein synthesis, and so does not require immediate early gene expression. We conclude that c-Myc-induced apoptosis does not result from a conflict of growth signals but appears to be a normal physiological aspect of c-Myc function whose execution is regulated by the availability of survival factors. We discuss the possible implications of these findings for models of mammalian cell growth in vivo. .

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References

    1. Immunol Today. 1993 Mar;14(3):126-30 - PubMed
    1. Mol Cell Biol. 1993 Apr;13(4):2432-40 - PubMed (V体育官网入口)
    1. Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3516-20 - PubMed
    1. J Immunol. 1993 Aug 15;151(4):1979-88 - PubMed
    1. Cell. 1993 Aug 27;74(4):597-608 - PubMed (VSports)

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