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. 1994 Dec 1;372(6505):425-32.
doi: 10.1038/372425a0.

Positional cloning of the mouse obese gene and its human homologue (V体育平台登录)

Y Zhang  1 , R Proenca, M Maffei, M Barone, L Leopold, J M Friedman
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Positional cloning of the mouse obese gene and its human homologue

"VSports" Y Zhang et al. Nature. .

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  • Nature 1995 Mar 30;374(6521):479

Abstract

The mechanisms that balance food intake and energy expenditure determine who will be obese and who will be lean VSports手机版. One of the molecules that regulates energy balance in the mouse is the obese (ob) gene. Mutation of ob results in profound obesity and type II diabetes as part of a syndrome that resembles morbid obesity in humans. The ob gene product may function as part of a signalling pathway from adipose tissue that acts to regulate the size of the body fat depot. .

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