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. 1995 Jan 13;267(5195):249-52.
doi: 10.1126/science.7809631.

Inhibition of ras-induced proliferation and cellular transformation by p16INK4

M Serrano  1 , E Gómez-Lahoz, R A DePinho, D Beach, D Bar-Sagi
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Inhibition of ras-induced proliferation and cellular transformation by p16INK4

M Serrano et al. Science. .

Abstract (V体育官网入口)

The cyclin-dependent kinase 4 (CDK4) regulates progression through the G1 phase of the cell cycle. The activity of CDK4 is controlled by the opposing effects of the D-type cyclin, an activating subunit, and p16INK4, an inhibitory subunit. Ectopic expression of p16INK4 blocked entry into S phase of the cell cycle induced by oncogenic Ha-Ras, and this block was relieved by coexpression of a catalytically inactive CDK4 mutant VSports手机版. Expression of p16INK4 suppressed cellular transformation of primary rat embryo fibroblasts by oncogenic Ha-Ras and Myc, but not by Ha-Ras and E1a. Together, these observations provide direct evidence that p16INK4 can inhibit cell growth. .

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