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Comparative Study
. 1995 Jun 15;55(12):2507-10.

"V体育ios版" Overexpression of Bcl-XS sensitizes MCF-7 cells to chemotherapy-induced apoptosis

V N Sumantran  1 , M W Ealovega, G Nuñez, M F Clarke, M S Wicha
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  • PMID: 7780958
Comparative Study

"V体育官网入口" Overexpression of Bcl-XS sensitizes MCF-7 cells to chemotherapy-induced apoptosis

V N Sumantran et al. Cancer Res. .

Abstract (VSports在线直播)

Resistance to apoptosis plays an important role in tumors that are refractory to chemotherapy VSports手机版. We report that Bcl-XL, which functions like Bcl-2 to inhibit apoptosis, is highly expressed in MCF-7 human breast carcinoma cells. We used Bcl-XS, a dominant negative inhibitor of Bcl-2 and Bcl-XL, to demonstrate the role of these genes in modulating chemotherapy-induced apoptosis. Bcl-XS overexpressed in MCF-7 cells by stable transfection does not affect viability by itself but induces a marked increase in chemosensitivity to VP-16 or taxol. Using an ELISA assay which quantitates DNA damage, we demonstrate that this sensitization is due to apoptosis, suggesting the therapeutic utility of targeting this pathway. .

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