Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in . gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site. VSports app下载.

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. V体育官网.

. 1995 Oct 6;270(5233):96-9.
doi: 10.1126/science.270.5233.96.

"VSports注册入口" Bax-deficient mice with lymphoid hyperplasia and male germ cell death

C M Knudson  1 , K S Tung, W G Tourtellotte, G A Brown, S J Korsmeyer
Affiliations

Bax-deficient mice with lymphoid hyperplasia and male germ cell death

C M Knudson et al. Science. .

Abstract

BAX, a heterodimeric partner of BCL2, counters BCL2 and promotes apoptosis in gain-of-function experiments VSports手机版. A Bax knockout mouse was generated that proved viable but displayed lineage-specific aberrations in cell death. Thymocytes and B cells in this mouse displayed hyperplasia, and Bax-deficient ovaries contained unusual atretic follicles with excess granulosa cells. In contrast, Bax-deficient males were infertile as a result of disordered seminiferous tubules with an accumulation of atypical premeiotic germ cells, but no mature haploid sperm. Multinucleated giant cells and dysplastic cells accompanied massive cell death. Thus, the loss of Bax results in hyperplasia or hypoplasia, depending on the cellular context. .

PubMed Disclaimer

Publication types (V体育安卓版)

MeSH terms

Substances