Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in VSports app下载. gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure V体育官网. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. .

. 1994 Apr 1;179(4):1317-30.
doi: 10.1084/jem.179.4.1317.

Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes

L A Casciola-Rosen  1 , G Anhalt, A Rosen
Affiliations

Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes (VSports注册入口)

L A Casciola-Rosen et al. J Exp Med. .

Abstract

Systemic lupus erythematosus is a multisystem autoimmune disease in which the autoantibody response targets a variety of autoantigens of diverse subcellular location. We show here that these autoantigens are clustered in two distinct populations of blebs at the surface of apoptotic cells VSports手机版. The population of smaller blebs contains fragmented endoplasmic reticulum (ER) and ribosomes, as well as the ribonucleoprotein, Ro. The larger blebs (apoptotic bodies) contain nucleosomal DNA, Ro, La, and the small nuclear ribonucleoproteins. These autoantigen clusters have in common their proximity to the ER and nuclear membranes, sites of increased generation of reactive oxygen species in apoptotic cells. Oxidative modification at these sites may be a mechanism that unites this diverse group of molecules together as autoantigens. .

PubMed Disclaimer

Comment in

  • Autoimmunity and apoptosis.
    Tan EM. Tan EM. J Exp Med. 1994 Apr 1;179(4):1083-6. doi: 10.1084/jem.179.4.1083. J Exp Med. 1994. PMID: 8145031 Free PMC article. Review. No abstract available.

References

    1. J Immunol Methods. 1990 May 25;129(2):207-10 - PubMed
    1. J Clin Invest. 1991 May;87(5):1490-5 - "VSports在线直播" PubMed
    1. Proc Natl Acad Sci U S A. 1984 Apr;81(7):1996-2000 - "VSports" PubMed
    1. J Clin Invest. 1984 Oct;74(4):1545-51 - "V体育安卓版" PubMed
    1. Histochem J. 1984 Nov;16(11):1171-91 - PubMed (V体育官网)

Publication types

MeSH terms