日 "VSports手机版" Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in . gov or VSports app下载. mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely V体育官网. .

. 1984 Aug 31;225(4665):935-8.
doi: 10.1126/science.6089334.

"V体育平台登录" Small DNA deletions creating avirulence in Streptococcus pyogenes

J G Spanier, S J Jones, P Cleary

Small DNA deletions creating avirulence in Streptococcus pyogenes

J G Spanier et al. Science. .

V体育平台登录 - Abstract

The M protein is the antigen on the surface of group A streptococci that allows these bacteria to resist phagocytosis VSports手机版. DNA encoding the M12 protein was cloned into Escherichia coli and used as an isotopically labeled hybridization probe to compare genomic DNA's isolated from M+ and M- isogenic cultures in an effort to elucidate the genetic basis of this variation. DNA's from two spontaneous, independent M- variants contained small (approximately 50 base pairs) deletions which were mapped to identical restriction fragments within or adjacent to the M protein coding sequence. Taken together with the pleiotropic nature of these deletions, this suggests that they define a regulatory switch. .

PubMed Disclaimer

V体育2025版 - Publication types

MeSH terms

LinkOut - more resources