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. 2022 Dec;13(4):19-31.
doi: 10.1177/19476035221126343. Epub 2022 Oct 28.

Minced Autologous Chondral Fragments with Fibrin Glue as a Simple Promising One-Step Cartilage Repair Procedure: A Clinical and MRI Study at 12-Month Follow-Up (VSports app下载)

M H H Wodzig  1 , M J M Peters, K S Emanuel  1   2 , P P W Van Hugten  1 , W Wijnen  1 , L M Jutten  1 , T A Boymans  1 , D V Loeffen  3 , P J Emans  1
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Minced Autologous Chondral Fragments with Fibrin Glue as a Simple Promising One-Step Cartilage Repair Procedure: A Clinical and MRI Study at 12-Month Follow-Up (V体育ios版)

M H H Wodzig et al. Cartilage. 2022 Dec.

Abstract

Objective: The aim of this study was to investigate early radiological and clinical outcome of autologous minced cartilage treatment as a single-step treatment option in patients with a chondral or osteochondral lesion (OCL) in the knee. VSports手机版.

Design: Eighteen patients with an OCL in the knee were included. Cartilage from healthy-appearing loose bodies and/or the periphery of the defect were minced into small chips and sealed in the defect using fibrin glue V体育安卓版. Preoperatively, and at 3 (n = 14) and 12 (n = 18) months follow-up, magnetic resonance imaging (MRI) was performed. The Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) 2. 0 score was used to assess the cartilage repair tissue on MRI at 12 months. The International Knee Documentation Score, Knee Injury and Osteoarthritis Outcome Score, EuroQoL-5D, and Visual Analogue Scale pain were collected preoperatively and 12 months after surgery. .

Results: Three months postoperative, MRI showed complete defect filling in 11 out of 14 patients. Mean MOCART 2. 0 score at 12 months was 65 V体育ios版. 0 ± 18. 9 with higher scores for lateral femoral chondral lesions compared to medial femoral chondral lesions (75. 8 ± 14. 3, 52. 5 ± 15. 8 respectively, P = 0. 02). Clinical and statistical significant improvements were observed in the patient-reported outcome measures at 12 months postoperatively compared to preoperatively. .

Conclusion: Treatment of OCLs using the autologous minced cartilage procedure resulted in good cartilage repair measured by MOCART 2. 0. Clinically relevant improvements were observed in the clinical scores. This study suggests autologous minced cartilage as a promising, single-step treatment for OCLs. VSports最新版本.

Keywords: cartilage lesion; cartilage repair; chondral lesion; knee; minced cartilage V体育平台登录. .

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Conflict of interest statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Defect of the lateral femoral condyle after debridement creating a stable viable cartilage wall (A). Loose, vital appearing chondral fragments collected from the suprapatellar pouch (B). Minced cartilage (C). Defect after implantation of the cartilage chips sealed with fibrin glue (D).
Figure 2.
Figure 2.
Top row: Pre-operative MR image showing the full thickness cartilage lesion with a 5mm bony defect at the lateral femoral condyle (A). MRI 3 months post-operatively showing complete fill of the defect (B). MRI 1 year post-operatively showing complete fill of the defect with good integration, no bony defect and minor subchondral oedema; MOCART 80, patient 5 (C). MR sequences A to C: PD FS, PD FS, PD FS. Middle row: Pre-operative MR image showing a full thickness cartilage lesion with a bony defect at the lateral aspect of the patella (D). MRI 3 months post-operatively showing complete fill of the defect (E). MRI 1 year post-operatively showing complete fill of the defect with good integration, no hypertrophy, homogeneous repair tissue with normal signal intensity, and no subchondral changes; MOCART 100, patient 1 (F). MR sequences D to F: PD TSE, FSE FS, T2 TSE. Bottom row: Pre-operative MR image showing a full thickness cartilage lesion with a bony defect at the lateral femoral condyle (G). MRI 3 months post-operatively showing partial fill of the defect (H). MRI 1 year post-operatively showing hypertrophy of the graft, good integration into adjacent cartilage, heterogenous structure of the RT and minor subchondral oedema; MOCART 70, patient 9 (I). MR sequences G to I: PD, T2 FS, T2 FS. MRI = magnetic resonance imaging; MOCART = Magnetic Resonance Observation of Cartilage Repair Tissue; PD = proton density; FS = fat suppression; TSE = turbo spin echo.
Figure 3.
Figure 3.
MOCART score per defect location. The asterisk depicts a statistically significant difference between the MOCART score of LFC and MFC lesions (p = 0.02). MOCART = Magnetic Resonance Observation of Cartilage Repair Tissue; LFC = lateral femoral condyle; MFC = medial femoral condyle.
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