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Review
. 2023 Jan;19(1):26-45.
doi: 10.1007/s12015-022-10449-2. Epub 2022 Aug 22.

The Role of NK Cells and Their Exosomes in Graft Versus Host Disease and Graft Versus Leukemia (VSports在线直播)

Alireza Zafarani  1 , Mahsa Taghavi-Farahabadi  2 , Mohammad Hossein Razizadeh  3 , Mohammad Reza Amirzargar  1 , Mansoure Mansouri  4 , Mohammad Mahmoudi  5
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V体育ios版 - The Role of NK Cells and Their Exosomes in Graft Versus Host Disease and Graft Versus Leukemia

Alireza Zafarani et al. Stem Cell Rev Rep. 2023 Jan.

Abstract

Natural killer (NK) cells are one of the innate immune cells that play an important role in preventing and controlling tumors and viral diseases, but their role in hematopoietic stem cell transplantation (HCT) is not yet fully understood. However, according to some research, these cells can prevent infections and tumor relapse without causing graft versus host disease (GVHD). In addition to NK cells, several studies are about the anti-leukemia effects of NK cell-derived exosomes that can highlight their roles in graft-versus-leukemia (GVL) VSports手机版. In this paper, we intend to investigate the results of various articles on the role of NK cells in allogeneic hematopoietic cell transplantation and also their exosomes in GVL. Also, we have discussed the antiviral effects of these cells in post-HCT cytomegalovirus infection. .

Keywords: Cytomegalovirus; Exosomes; GVHD; GVL; Hematopoietic stem cell transplantation; NK cell. V体育安卓版.

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VSports - References

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