V体育安卓版 - Prognostic analysis of cuproptosis-related gene in triple-negative breast cancer
- PMID: 35979353
- PMCID: PMC9376234
- DOI: V体育官网入口 - 10.3389/fimmu.2022.922780
Prognostic analysis of cuproptosis-related gene in triple-negative breast cancer
Abstract
Background: Cuproptosis is a copper-dependent cell death mechanism that is associated with tumor progression, prognosis, and immune response. However, the potential role of cuproptosis-related genes (CRGs) in the tumor microenvironment (TME) of triple-negative breast cancer (TNBC) remains unclear VSports手机版. .
Patients and methods: In total, 346 TNBC samples were collected from The Cancer Genome Atlas database and three Gene Expression Omnibus datasets, and were classified using R software packages. The relationships between the different subgroups and clinical pathological characteristics, immune infiltration characteristics, and mutation status of the TME were examined. Finally, a nomogram and calibration curve were constructed to predict patient survival probability to improve the clinical applicability of the CRG_score V体育安卓版. .
Results: We identified two CRG clusters with immune cell infiltration characteristics highly consistent with those of the immune-inflamed and immune-desert clusters. Furthermore, we demonstrated that the gene signature can be used to evaluate tumor immune cell infiltration, clinical features, and prognostic status. Low CRG_scores were characterized by high tumor mutation burden and immune activation, good survival probability, and more immunoreactivity to CTLA4, while high CRG_scores were characterized by the activation of stromal pathways and immunosuppression. V体育ios版.
Conclusion: This study revealed the potential effects of CRGs on the TME, clinicopathological features, and prognosis of TNBC. The CRGs were closely associated with the tumor immunity of TNBC and are a potential tool for predicting patient prognosis. Our data provide new directions for the development of novel drugs in the future VSports最新版本. .
Keywords: cuproptosis; immunotherapy; triple-negative breast cancer; tumor microenvironment; tumor mutation burden. V体育平台登录.
Copyright © 2022 Sha, Si, Wu, Chen, Xiong, Xu, Liu, Mei, Wang and Li VSports注册入口. .
Conflict of interest statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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