"V体育官网" Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in . gov or . mil VSports app下载. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure V体育官网. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. .

. 2022 Apr 5;15(1):128.
doi: 10.1186/s13104-022-06008-0.

Serum IGF-1 in patients with rheumatoid arthritis: correlation with disease activity

Hanna Lee  1 , Young Sun Suh  2 , Sang-Il Lee  1 , Yun-Hong Cheon  1 , Mingyo Kim  1 , Hae Sook Noh  3 , Hyun-Ok Kim  4
Affiliations

Serum IGF-1 in patients with rheumatoid arthritis: correlation with disease activity

Hanna Lee et al. BMC Res Notes. .

Abstract

Objective: Insulin-like growth factor (IGF)-1 participates in modulating immunity and inflammation VSports手机版. Its bioactivity is controlled by six IGF-binding proteins (IGFBP-1 to IGFBP-6). In particular, the IGFBP-3 level is reportedly linked to the disease activity of rheumatoid arthritis (RA), consistent with our previous study. Therefore, the present study aimed to reproduce the previous results. .

Results: The serum IGFBP-3 level was not significantly different among the three groups according to disease activity based on the DAS28-ESR/CRP (p > 0. 05) but was significantly different between the low- and high-disease-activity groups based on the DAS28-CRP (p = 0. 036). Meanwhile, the interleukin-6 (IL-6) level moderately correlated with DAS28-CRP (Spearman's rho = 0 V体育安卓版. 583, p < 0. 001). .

Keywords: Disease activity; Insulin-like growth factor binding protein-3; Insulin-like growth factor-1; Rheumatoid arthritis V体育ios版. .

PubMed Disclaimer

Conflict of interest statement (V体育官网)

The authors declare that they have no competing interests.

References

    1. Lu MC, Yu CL, Chen HC, Yu HC, Huang HB, Lai NS. Increased miR-223 expression in T cells from patients with rheumatoid arthritis leads to decreased insulin-like growth factor-1-mediated interleukin-10 production. Clin Exp Immunol. 2014;177:641–651. doi: 10.1111/cei.12374. - "VSports手机版" DOI - PMC - PubMed
    1. Heemskerk VH, Daemen MA, Buurman WA. Insulin-like growth factor-1 (IGF-1) and growth hormone (GH) in immunity and inflammation. Cytokine Growth Factor Rev. 1999;10:5–14. doi: 10.1016/S1359-6101(98)00022-7. - DOI - PubMed
    1. Matsumoto T, Tsurumoto T. Inappropriate serum levels of IGF-1 and IGFBP-3 in patients with rheumatoid arthritis. Rheumatology (Oxford) 2002;41:352–353. doi: 10.1093/rheumatology/41.3.352. - "VSports注册入口" DOI - PubMed
    1. Delafontaine P, Song YH, Li Y. Expression, regulation, and function of IGF-1, IGF-1R, and IGF-1 binding proteins in blood vessels. Arterioscler Thromb Vasc Biol. 2004;24:435–444. doi: 10.1161/01.ATV.0000105902.89459.09. - DOI - PubMed
    1. Jogie-Brahim S, Feldman D, Oh Y. Unraveling insulin-like growth factor binding protein-3 actions in human disease. Endocr Rev. 2009;30:417–437. doi: 10.1210/er.2008-0028. - V体育2025版 - DOI - PMC - PubMed

MeSH terms

V体育官网 - Substances