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. 2021 Nov;25(11):1007-1016.
doi: 10.1080/14728222.2021.2011859. Epub 2021 Dec 20.

"V体育2025版" PD-L1 and Notch as novel biomarkers in pancreatic sarcomatoid carcinoma: a pilot study

Nicola Silvestris  1   2 , Antonella Argentiero  1 , Oronzo Brunetti  1 , Margherita Sonnessa  3 , Fulvia Colonna  4 , Sabina Delcuratolo  5 , Claudio Luchini  6   7 , Aldo Scarpa  6   7   8 , Sara Lonardi  9   10 , Floriana Nappo  9   11 , Matteo Fassan  12   13 , Antonio Giovanni Solimando  1   2 , Livia Fucci  4 , Concetta Saponaro  3
Affiliations

PD-L1 and Notch as novel biomarkers in pancreatic sarcomatoid carcinoma: a pilot study

Nicola Silvestris et al. Expert Opin Ther Targets. 2021 Nov.

Abstract

Background: The improved immunological understanding revealed the tumor microenvironment as an appealing driver to restore the immune response against cancer cells resulting in a paradigm shift in the oncology field. However, the complexity of the tumor milieu suggests the role of several pathways linking in immunomodulation mechanisms VSports手机版. Pancreatic cancer represents a model of the intricate relationship between malignant cells and their surrounding neighborhood. .

Research design and methods: In this study, we analyzed, retrospectively, six cases of rare pancreatic sarcomatoid carcinoma (PSC) and evaluated the expression of PD-L1 and Notch, aiming to explore new attributes in immunophenotype. V体育安卓版.

Results: PD-L1 CPS ≥ 1was common in PSCs (83%) with half samples expressing PD-L1 CPS ≥ 50 V体育ios版. Notch1 and Notch3 demonstrated a high range of expression. A direct significant correlation between PD-L1 and Notch3 overexpression (r = 0. 7; p = 0. 036) has been observed. Immunofluorescence studies revealed a co-localization of Notch3 and PD-L1 when both proteins were over-expressed within cytoplasmic or membranous compartments of the same cells. .

Conclusions: Our data identify a unique biological characterization of this rare pancreatic histotype VSports最新版本. These findings provide a rationale for future studies evaluating the potential crosstalk between PD-L1/PD-1 axis and Notch pathways and prompting the development of novel therapeutics strategy. .

Keywords: Notch; pancreatic sarcomatoid carcinoma; pd-l1; rare pancreatic carcinoma V体育平台登录. .

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