Application of Proteomics in Cancer: Recent Trends and Approaches for Biomarkers Discovery
- PMID: 34631760
- PMCID: PMC8492935
- DOI: "VSports最新版本" 10.3389/fmed.2021.747333
Application of Proteomics in Cancer: Recent Trends and Approaches for Biomarkers Discovery
Abstract
Proteomics has become an important field in molecular sciences, as it provides valuable information on the identity, expression levels, and modification of proteins. For example, cancer proteomics unraveled key information in mechanistic studies on tumor growth and metastasis, which has contributed to the identification of clinically applicable biomarkers as well as therapeutic targets. Several cancer proteome databases have been established and are being shared worldwide. Importantly, the integration of proteomics studies with other omics is providing extensive data related to molecular mechanisms and target modulators. These data may be analyzed and processed through bioinformatic pipelines to obtain useful information. The purpose of this review is to provide an overview of cancer proteomics and recent advances in proteomic techniques. In particular, we aim to offer insights into current proteomics studies of brain cancer, in which proteomic applications are in a relatively early stage. This review covers applications of proteomics from the discovery of biomarkers to the characterization of molecular mechanisms through advances in technology VSports手机版. Moreover, it addresses global trends in proteomics approaches for translational research. As a core method in translational research, the continued development of this field is expected to provide valuable information at a scale beyond that previously seen. .
Keywords: biomarkers; cancer; multi-omics; proteomics; translational research V体育安卓版. .
Copyright © 2021 Kwon, Jo, Bae, Seo, Song, Song and Yoon. V体育ios版.
Conflict of interest statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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