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. 2021 Nov 19:579:153-160.
doi: 10.1016/j.bbrc.2021.09.061. Epub 2021 Sep 25.

VSports app下载 - An elevated deoxycholic acid level induced by high-fat feeding damages intestinal stem cells by reducing the ileal IL-22

Jingxian Xu  1 , Dan Huang  2 , Xianjun Xu  1 , Xiaowan Wu  3 , Leheng Liu  1 , Wenlu Niu  1 , Lungen Lu  4 , Hui Zhou  5
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V体育官网入口 - An elevated deoxycholic acid level induced by high-fat feeding damages intestinal stem cells by reducing the ileal IL-22

Jingxian Xu et al. Biochem Biophys Res Commun. .

V体育官网入口 - Abstract

Long-term high-fat diet (HFD) destroys the intestinal mucosal barrier by damaging intestinal stem cells (ISCs) VSports手机版. A HFD can increase the concentration of intestinal deoxycholic acid (DCA) and decrease the secretion of interleukin-22 (IL-22), which plays an important role in the proliferation, repair and regeneration of ISCs. We hypothesized that increased level of intestinal DCA induced by a HFD leads to ISC dysfunction by reducing the IL-22 levels in intestinal tissues. In this study, 2 weeks of a DCA diet or a HFD damaged ileal ISC and its proliferation and differentiation, resulting in a decrease in Paneth cells and goblet cells. Importantly, 2 weeks of a DCA diet or a HFD also reduced ileal IL-22 concentration, accompanied by a decreased number of group 3 innate lymphoid cells in ileal mucosa, which produce IL-22 after intestinal injury. Concurrent feeding with bile acid binder cholestyramine prevented all these changes induced by a HFD. In addition, in vitro study further confirmed that exogenous IL-22 reversed the decline in the proliferation and differentiation of ileal ISCs induced by DCA stimulation. Collectively, these results revealed that the decrease in intestinal IL-22 induced by DCA may be a novel mechanism by which HFD damages ISCs. The administration of IL-22 or a bile acid binder may provide novel therapeutic targets for the metabolic syndrome caused by a HFD. .

Keywords: Deoxycholic acid; Group 3 innate lymphoid cell; High-fat diet; Interleukin 22; Intestinal stem cell. V体育安卓版.

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Declaration of competing interest The authors declare that they have no competing interests.

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