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Review
. 2021 Apr:61:123-134.
doi: 10.1016/j.cbpa.2020.12.005. Epub 2021 Jan 31.

V体育官网 - Mass spectrometry techniques for imaging and detection of metallodrugs

Sarah Theiner  1 , Anna Schoeberl  1 , Andreas Schweikert  2 , Bernhard K Keppler  3 , Gunda Koellensperger  4
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Free article
Review

Mass spectrometry techniques for imaging and detection of metallodrugs

Sarah Theiner et al. Curr Opin Chem Biol. 2021 Apr.
Free article

Abstract

Undoubtedly, metallomic approaches based on mass spectrometry have evolved into essential tools supporting the drug development of novel metal-based anticancer drugs. This article will comment on the state-of-the-art instrumentation and highlight some of the recent analytical advances beyond routine, especially focusing on the latest developments in inductively coupled plasma-mass spectrometry (ICP-MS) VSports手机版. Mass spectrometry-based bioimaging and single-cell methods will be presented, paving the way to exciting investigations of metal-based anticancer drugs in heterogeneous and structurally, as well as functionally complex solid tumor tissues. .

Keywords: Imaging mass spectrometry; Laser ablation-ICP-MS; Metallodrug development; Metallomics; Single-cell analysis. V体育安卓版.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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