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Review
. 2020 Dec 7;13(1):168.
doi: 10.1186/s13045-020-00998-9.

V体育安卓版 - Chimeric antigen receptor-engineered natural killer cells for cancer immunotherapy

Ahmet Yilmaz  1 , Hanwei Cui  1 , Michael A Caligiuri  2   3   4   5 , Jianhua Yu  6   7   8   9
Affiliations
Review

Chimeric antigen receptor-engineered natural killer cells for cancer immunotherapy

Ahmet Yilmaz et al. J Hematol Oncol. .

V体育平台登录 - Abstract

Natural killer (NK) cells are a critical component of the innate immune system. Chimeric antigen receptors (CARs) re-direct NK cells toward tumor cells carrying corresponding antigens, creating major opportunities in the fight against cancer. CAR NK cells have the potential for use as universal CAR cells without the need for human leukocyte antigen matching or prior exposure to tumor-associated antigens. Exciting data from recent clinical trials have renewed interest in the field of cancer immunotherapy due to the potential of CAR NK cells in the production of "off-the-shelf" anti-cancer immunotherapeutic products. Here, we provide an up-to-date comprehensive overview of the recent advancements in key areas of CAR NK cell research and identify under-investigated research areas. We summarize improvements in CAR design and structure, advantages and disadvantages of using CAR NK cells as an alternative to CAR T cell therapy, and list sources to obtain NK cells. In addition, we provide a list of tumor-associated antigens targeted by CAR NK cells and detail challenges in expanding and transducing NK cells for CAR production. We additionally discuss barriers to effective treatment and suggest solutions to improve CAR NK cell function, proliferation, persistence, therapeutic effectiveness, and safety in solid and liquid tumors. VSports手机版.

Keywords: Cancer immunotherapy; Chimeric antigen receptor; Natural killer cells; T cells. V体育安卓版.

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Conflict of interest statement

M. A V体育ios版. Caligiuri and J. Yu are the co-founders of CytoImmune Therapeutics, Inc. The other authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Representative steps in CAR NK cell manufacturing for immunotherapy, RCL/RCR replication competent lentivirus/retrovirus measured by qPCR for detection of DNA encoding a viral envelope
See this image and copyright information in PMC

References

    1. Spits H, Artis D, Colonna M, Diefenbach A, Di Santo JP, Eberl G, Koyasu S, Locksley RM, McKenzie AN, Mebius RE, et al. Innate lymphoid cells–a proposal for uniform nomenclature. Nat Rev Immunol. 2013;13(2):145–149. doi: 10.1038/nri3365. - DOI - PubMed
    1. Ishizuka IE, Constantinides MG, Gudjonson H, Bendelac A. The innate lymphoid cell precursor. Annu Rev Immunol. 2016;34:299–316. doi: 10.1146/annurev-immunol-041015-055549. - DOI - PubMed
    1. Walker JA, Barlow JL, McKenzie AN. Innate lymphoid cells—how did we miss them? Nat Rev Immunol. 2013;13(2):75–87. doi: 10.1038/nri3349. - "VSports在线直播" DOI - PubMed
    1. Vivier E, Tomasello E, Baratin M, Walzer T, Ugolini S. Functions of natural killer cells. Nat Immunol. 2008;9(5):503–510. doi: 10.1038/ni1582. - DOI - PubMed
    1. Yu J, Freud AG, Caligiuri MA. Location and cellular stages of natural killer cell development. Trends Immunol. 2013;34(12):573–582. doi: 10.1016/j.it.2013.07.005. - DOI (V体育安卓版) - PMC - PubMed

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